Progesterone and estriven regulate cellular proliferation, and their receptors are identified in the nuclei of cancer cells such as breast, endometrium ovary, kidney and brain. Presence of progesterone receptor(PR) in breast cancer is very
impotant
to
the endocrine therapy.
Determination of progesterone receptor was usually carried out immunohistochemistry using frozen section, but frozen section had a problem of freezing artifact. In recent years, immunohistochemistry for PR was available to paraffin section.
In this study, another attempt to immunohistochemical stain for PR in paraffin sections of 53 cases of breast cancer done.
@ES The results were as follows.
@EN 1) In immunohistochemistry for PR, in 22 of 46 cases of infiltrating ductal carcinoma were revealed positive reation, and 3 cases of medullary carcinoma. 3 cases of medullary carcinoma. 3 cases of mucinous carcinoma, 1 case of infiltrating
lobular
carcinoma were negative.
2) Lymph node metastasis was identified in 7 cases of infiltrating ductal carcinoma which were positive for PR and 9 cases of negative reaction for PR.
3) Iimmunohistochemistry for PR in paraffin sections of breast cancer has a good advantage in preservation of tissue architecture and retrospective study.
The determination of PR in paraffin sections of breast cancer may be useful to the endocrine therapy and useful in retrospective study.
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